Clarke, died at a hospital in Sri Lanka on Wednesday, his aide Rohan de Silva told AFP.
He was 90. "I have no regrets and no more personal ambitions," said the writer, who was confined for the past three decades to a wheelchair because of the effects of childhood polio.
Clarke, who shot to fame after writing "2001: A Space Odyssey," had been in and out of hospital since his 90th birthday in December and had breathing difficulties, de Silva said.
"Sir Arthur passed away a short while ago at the Apollo Hospital," de Silva said.
Clarke, who in 1945 predicted the establishment of communication satellites, has written more than 80 books. He was Sri Lanka's best-known resident guest and has a scientific academy named after him.
His vallet, W. K. M. Dharmawardena, said funeral arrangements would be finalised after his close family returned to the island from Australia.
Dharmawardena said Clarke's condition began to deteriorate in recent weeks and he had been in hospital for the past four days.
Clarke marked his birthday on December 16 wishing for peace in his adopted home of Sri