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She had been admitted to the hospital on Sunday evening, having collapsed after complaining of a sudden headache.
"Mrs Roddick was admitted to the hospital's Intensive Care Unit and her husband Gordon and two daughters, Sam and Justine, were with her when she died," a statement from the family said.
Roddick announced in February that she was suffering from the viral disease hepatitis C, contracted through a blood transfusion during the birth of her youngest daughter, Sam, in 1971.
She also suffered from cirrhosis of the liver, a common long-term effect of the disease.
At the time, she said hepatitis C had to be given more prominence as a "public health challenge," adding: "What I can say is that having hep C means that I live with a sharp sense of my own mortality, which in many ways makes life more vivid and immediate.
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"It makes me even more de