"The UNHCR is deeply concerned about the recent drowning of 10 Sri Lankan refugees travelling by boat to India," the agency said in a statement.
It said women and children may also be subject to sexual abuse.
"Many refugees fleeing localized violence are being put at great risk by unscrupulous traffickers who operate unseaworthy and overcrowded vessels," the agency said.
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It said the drowning on May 19 was the latest in a series of incidents involving Sri Lankan refugees travelling to the Indian state of Tamil Nadu.
Some have been abandoned at sea while others have died when their vessels capsized.
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"While everyone has an inalienable right to claim asylum, UNHCR urges those planning on making the perilous journey to Tamil Nadu, to carefully consider the serious danger